In this verse, God promises to make a nation out of Ishmael for Abraham's sake. This is similar to when Lot was saved. Lot was saved for Abraham's sake.
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Explanation posted by John Wesley on 2007-01-01 00:00:00
The casting out of Ishmael was not his ruin. He shall be a nation because he is thy seed - We are not sure that it was his eternal ruin. It is presumption to say, that all these who are left out of the external dispensation of God's covenant are excluded from all his mercies. Those may be saved who are not thus honoured.